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The main aim of this study was to characterize the association between low-energy diet and risk for type 2 diabetes in the general population. We studied dietary data for 2,809 cases and 15,770 non-cases among Danish women.
Participants were categorized into quintiles of low-energy diet based on intakes of total energy, fat, protein and carbohydrate.
Diabetes risk was inversely associated with increasing intakes of carbohydrate and positively associated with increasing intakes of protein and fat. A Cox proportional hazards model that simultaneously adjusted for risk factors for type 2 diabetes showed that type 2 diabetes risk was inversely associated with increasing intakes of carbohydrate and positively associated with increasing intakes of protein and fat.
This study suggests that the association between low-energy diet and risk for type 2 diabetes is not mediated by adiposity or markers of insulin resistance.
The preprint of this article is available in electronic format at 0b46394aab