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Hashim Nadeem is the author of the book Abdullah Novel Pdf. The author of this book is a famous Pakistani novelist, fiction writer, and film producer. He wrote some super hit novels. He is a TV drama producer also and produced some top-class serials for private tv channels of Pakistan.
The book Abdullah is a novel by Hashim Nadeem. It was published in the episode earlier and later in a book format. He dramatized this story later, which was very popular in the viewers. The book Abdullah Novel Pdf is a romantic story. A man fell in love with a girl and faced hardships and struggle a lot. This love converted in love for Allah.
I hope you will like the book Abdullah Novel Pdf and share it. Here on the site, you can download Hashim Nadeem Novels in pdf. You may also like the other novel Muqadas Novel Urdu, Daulat Kay Pujari Novel Complete, & Bachpan Ka December.
Object detection is the method of identifying the class instance to which the object belongs. There are several types of detection, such as single-class object detection and multiclass object detection . Object detection has been applied in a wide field of medical images because of its precise effect on discovering diseases of all kinds. The convolutional neural network (CNN) is widely used to extract image characteristics and detect different objects. It is a neural network that operates on the principle of weight sharing. The convolution is an integral part of a function that explains how one function interferes with another. The size and the number of images, the number of working layers, and the form of activation functions used in CNNs vary . Variables of CNNs are selected experimentally and on a trial-and-error basis. Besides, every CNN consists of several layers, the most important of which are the convolutional and subsampling (pooling) layers . Figure 2 shows an illustration of CNN architecture.
Therefore, they must perform a CT scan periodically to ensure that cancer in other organs has not spread to the kidneys. Besides, some cases are suffering from a nephrectomy or part of it due to RCC, and their condition must be monitored to ensure the safety of kidney function and that the tumor does not spread. Table 2 and Figure 6 show an analysis of the gender situation for all cases in the dataset.
Figure 12 shows a statistical analysis of the location of the tumor. For the left kidney, there are 21 cases in the upper, 17 cases are healthy, 11 cases in the lower, and 9 cases in the middle. While on the other hand, for the right kidney, there are 24 cases of healthy, 18 cases in the upper, 8 cases undefined, 7 cases in the lower, and one case in the middle. Based on these analyzes, we found that most of the tumors in the right kidney are located in the upper part, and the lower part and most of the tumors in the left kidney are located in the upper, middle, and lower parts. The healthy label means that there is no tumor in this kidney. It is possible that the tumor is in one kidney and the other is healthy. The undefined label means that this kidney may have been partially or completely nephrectomy, or it may be that the expert is unable to diagnose the location of the tumor, or it may be that the scan is not clear enough to determine the exact location of the tumor due to not taking the contrast material or because the patient moved during the CT test.
The adrenal glands are vital organs where steroidogenesis (in adrenal cortex) and catecholamine production (adrenal medulla) take place. The adrenal cortex has three compartments: zona glomerulosa, zona fasciculata, and zona reticularis  (Fig. 1). In the first step of the steroidogenesis StAR transports the cholesterol across the membrane, and then cholesterol is converted pregnenolone by the P450 side chain cleavage enzyme . Within the zona glomerulosa, HSD3B2 converts pregnenolone to progesterone, which eventually is converted into aldosterone by a series of enzymatic processes involving CYP21A2 and aldosterone synthase . In the zona fasciculata, CYP17A1 hydroxylates pregnenolone to form 17-hydroxyprogesterone (17OHP) which is then converted via several enzymes, including CYP11B1 and HSD3B2, to form cortisol. In the zona reticularis, 17-hydroxypregnenolone is converted to DHEA by CYP17A1. Then, HSD3B2 converts DHEA to androstenedione, which is a precursor of sex hormones . The conversion of the Δ5-3β-hydroxysteroids (pregnenolone, 17-hydroxypregnenolone, and DHEA) to a Δ4-3-ketosteroids (progesterone, 17OHP, and androstenedione) by HSD3B2 involves dehydrogenation followed by an isomerization reaction . Similarly, within the Leydig cells in the testis, cholesterol is converted to pregnenolone, 17-hydroxypregnenolone, DHEA and androstenedione. HSD17B3/AKR1C3 converts androstenedione or androstenediol to testosterone . DHEA is converted by SULT2A1 to the more stable sulfated form (DHEAS). DHEAS has longer half-life (
HSD3B2 catalyzes reactions responsible for synthesis of a 3-keto-Δ4 A-ring, which is an essential part of endogenous mineralocorticoids, glucocorticoids, progestins, and androgens [3, 12, 24]. As a result, 3βHSD2D impairs the synthesis of progesterone, the precursor hormone of aldosterone, 17OHP, the precursor for cortisol, androstenedione, testosterone, and estrogen in the adrenal glands and gonads [13, 24]. Reduced levels of cortisol decrease the negative feedback on the pituitary gland causing excess ACTH production. Subsequently, ACTH drives the accumulation of β-hydroxy-Δ5-steroids pregnenolone, 17-hydroxypregnenolone, and DHEA, and their sulfates . These precursor steroids cannot compensate for the cortisol and aldosterone deficiencies resulting in electrolyte disturbances and SW in most patients . In the peripheral tissues, the intact isoenzyme HSD3B1 enzyme converts circulating DHEA to testosterone .
Elevated level of androstenedione leads to relatively high level of testosterone in females, however, it fails to achieve full compensation for absence of testosterone synthesis in males. In 46,XY neonates testosterone deficiency causes genital ambiguity. On the other hand, in 46,XX neonates, the relatively high level of testosterone may cause clitoromegaly and partial labioscrotal fusion. In addition, undiagnosed females may present with precocious pubarche, acne, hirsutism, and menstrual disturbances .
Within the month of Rabīʿ al-Awwal, more than half a dozen opinions exist. Out of all of these dates, the two dates of the 8th and the 10th were in fact more popular opinions in the first five centuries of Islam, and in particular the former opinion was given greater credence. Why, then, is the date of the 12th of Rabīʿ al-Awwal considered the most popular in our times, so much so that most people are unaware of alternate opinions? This question is all the more compelling in light of the fact that Ibn Isḥāq narrates this opinion without any reference. This can be explained, and Allah knows best, by two factors.
Jazak Allah kheir for this attempt. I do however have an elementary question on this topic. Besides the fact that Muhammad (pbuh) is our prophet and we love him and want to celebrate his life and remember his deeds and message. Why is it important to know the date of his birth? If I know Bedouin culture, few if any know the date of their birth. Many know the year based on a major event that took place in that year based on someone, perhaps family, related it to them at an older age. This phenomenon still exists among many in the Gulf where birth certificates did not exist for a long time. As such, birthdays and birthday celebrations have not been a significant part of the culture. 2b1af7f3a8